Nonlinear envelope equation for broadband optical pulses in quadratic media

We derive a nonlinear envelope equation to describe the propagation of broadband optical pulses in second order nonlinear materials. The equation is first order in the propagation coordinate and is valid for arbitrarily wide pulse bandwidth. Our approach goes beyond the usual coupled wave description of $\chi^{(2)}$ phenomena and provides an accurate modelling of the evolution of ultra-broadband pulses also when the separation into different coupled frequency components is not possible or not profitable

Avaliação de inseticidas para o controle de Oiketicus kirbyi (Lands-Guilding, 1827) (Lep. Psychidae) em laboratório.

Devido à falta de informações sobre o efeito de inseticidas para o controle de O. kirbyi nas culturas da uva e pêssego, este trabalho teve como objetivo avaliar o efeito de lagarticidas sobre a espécie em laboratório (T=24°C±2 e UR 70% ± 10 e fotofase 14 horas).Resumo

Bioecologia e controle do bicho do cesto Oiketicus kirbyi (Guilding, 1927) (Lepidoptera: Psychidae) em pessegueiro e videira.

Este comunicado técnico tem como objetivo apresentar informações sobre a bioecologia do bicho do cesto e estratégias de controle que podem ser empregadas para o manejo da espécie nas culturas do pessegueiro e da videira.bitstream/item/81774/1/cot132-1.pd

Bronchodilating effects of extrafine beclometasone dipropionate and formoterol fumarate via pressurized metered dose inhaler in asthmatic children

Introduction: in asthmatic children older than 5 years, the GINA guidelines 2012 update recommend to add inhaled long-acting b2- agonists (LABA) when the disease is not adequately controlled with inhaled corticosteroids (ICS) alone. Controlled studies have shown that fixed combination therapies are as effective as giving each drug separately and may increase patients’ compliance. A paediatric extrafine fixed combination of beclometasone dipropionate (BDP) and formoterol fumarate (FF) via pressurized metered dose inhaler (pMDI) containing 50mg of BDP and 6mg of FF per actuation (CHF1535) was developed by Chiesi Farmaceutici S.p.A. (Parma, Italy)

Spatial beam self-cleaning in second-harmonic generation

We experimentally demonstrate the spatial self-cleaning of a highly multimode optical beam, in the process of second-harmonic generation in a quadratic nonlinear potassium titanyl phosphate crystal. As the beam energy grows larger, the output beam from the crystal evolves from a highly speckled intensity pattern into a single, bell-shaped spot, sitting on a low energy background. We demonstrate that quadratic beam cleanup is accompanied by significant self-focusing of the fundamental beam, for both positive and negative signs of the linear phase mismatch close to the phase-matching condition

Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish

Aim We aimed at identifying potential roles of vesicular monoamine transporter 2, also known as Solute Carrier protein 18 A2 (SLC18A2) (hereafter, Vmat2), in brain monoamine regulation, their turnover, behaviour and brain development using a novel zebrafish model. Methods A zebrafish strain lacking functional Vmat2 was generated with the CRISPR/Cas9 system. Larval behaviour and heart rate were monitored. Monoamines and their metabolites were analysed with high-pressure liquid chromatography. Amine synthesising and degrading enzymes, and genes essential for brain development, were analysed with quantitative PCR, in situ hybridisation and immunocytochemistry. Results The 5-bp deletion in exon 3 caused an early frameshift and was lethal within 2 weeks post-fertilisation. Homozygous mutants (hereafter, mutants) displayed normal low locomotor activity during night-time but aberrant response to illumination changes. In mutants dopamine, noradrenaline, 5-hydroxytryptamine and histamine levels were reduced, whereas levels of dopamine and 5-hydroxytryptamine metabolites were increased, implying elevated monoamine turnover. Consistently, there were fewer histamine, 5-hydroxytryptamine and dopamine immunoreactive cells. Cellular dopamine immunostaining, in wild-type larvae more prominent in tyrosine hydroxylase 1 (Th1)-expressing than in Th2-expressing neurons, was absent in mutants. Despite reduced dopamine levels, mutants presented upregulated dopamine-synthesising enzymes. Further, in mutants the number of histidine decarboxylase-expressing neurons was increased, notch1a and pax2a were downregulated in brain proliferative zones. Conclusion Lack of Vmat2 increases monoamine turnover and upregulates genes encoding amine-synthesising enzymes, including histidine decarboxylase. Notch1a and pax2a, genes implicated in stem cell development, are downregulated in mutants. The zebrafish vmat2 mutant strain may be a useful model to study how monoamine transport affects brain development and function, and for use in drug screening.Peer reviewe

Avaliação de formulações de iscas tóxicas para a supressão populacional de Ceratitis capitata (Wied., 1824) (Diptera: Tephritidae) em uva fina de mesa.

A mosca-do-mediterrâneo Ceratitis capitata é a principal praga da cultura da videira na região do Submédio São Francisco. Nesse estudo de caso, foi avaliado o efeito de formulações de iscas tóxicas de pronto uso (Gelsura® e Success* 0.02CB®) e do atrativo Anamed® associado ao inseticida espinosade (Tracer®) na supressão populacional de C. capitata em uva fina de mesa da cultivar Sugar Crisp® em Lagoa Grande, BA